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Hotels in Opelousas    Below is only a selection of Opelousas Hotels. Search them all with the search box on the right.    Low Rate Guarantee! Read more Low Rate Guarantee Best Western Of Opelousas - Opelousas 5791 I-49 S Service Road Opelousas, LA 70570-0726 Information The Best Western of Opelousas, a brand new Best Western located in Opelousas, offers both leisure and business travelers alike, a warm friendly atmosphere. Surrounded by a var More Check Rates Days Inn And Suites Opelousas - Opelousas 5761 I-49 South Service Road Opelousas, LA 70570 Information 4 Sunburst Newest Days Inn in the area Easy access to I-49 Only 20 miles from Lafayette Outdoor pool Complimentary High Speed Wireless Internet Restaurants are within walking More Check Rates Holiday Inn Hotel & Suites Opelousas - Opelousas 5696 I-49 North Service Rd. Opelousas, LA 70570 Information The Holiday Inn Hotels and Suites Opelousas. Located in the heart of Acadiana, our hotel offers 75 luxurious guest rooms and suites. Home of the annual Yambilee Festival, pref More Check Rates Americas Best Value Inn - Opelousas 4165 I-49 Service Road South Opelousas, LA 70570 Information Welcome to the Americas Best Value Inn of Opelousas, LA. We are conveniently located off of I-49 at exit 15/Harry Guilbeau Road for easy on and off highway access. Our 2-story More Check Rates

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