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Hotels in Picayune    Below is only a selection of Picayune Hotels. Search them all with the search box on the right.    Low Rate Guarantee! Read more Low Rate Guarantee Days Inn - Picayune - Picayune 450 S. Lofton Ave. Picayune, MS 39466 Information Beautifully appointed hotel within one hour of Biloxi casinos and New Orleans More Check Rates Comfort Inn Picayune - Picayune 550 South Lofton Dr. Picayune, MS 39466 Information Within 2 miles of historic district and antique shops. Within 1 hour of New Orleans, LA and Gulfport casinos. Free high speed Internet access in all rooms. More Check Rates

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