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Hotels in Lake City    Below is only a selection of Lake City Hotels. Search them all with the search box on the right.    Low Rate Guarantee! Read more Low Rate Guarantee Days Inn Lake City - Lake City 170 South Ron Mcnair Blvd Lake City, SC 29560 Information Days Inn of Lake City SC is located on Highway 52, accessible from Rt 378 off I-95. We are a family friendly motel in a quite, peaceful area within walking distance to our dow More Check Rates Holiday Inn Express Lake City - Lake City 202 Ron Mcnair Blvd. Lake City, SC 29560 Information Our Holiday Inn Express Hotel ® Lake City is located in the eastern section of the South Carolina in Florence County at the junction of US Highway 378 & US Highway 52, cent More Check Rates

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