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Hotels in Seneca    Below is only a selection of Seneca Hotels. Search them all with the search box on the right.    Low Rate Guarantee! Read more Low Rate Guarantee Best Western Executive Inn - Seneca 511 Us Highway 123 Bypass Seneca, SC 29678 Information Find great customer service and amenities while staying at this full service Seneca, South Carolina hotel. Situated right off South Carolina's US Highway 123, the Best Western More Check Rates Days Inn Seneca/Clemson - Seneca 11015 Radio Station Rd. Seneca, SC 29678 Information Our motel is surrounded by lakes with the mountains nearby. There are numerous restaurants in the area, a cinema, shopping areas within walking distance and the hospital is o More Check Rates Jameson Inn Seneca - Seneca 226 Hi-Tech Road Seneca, SC 29678 Information Featuring true Southern Hospitality, Legendary Service, white colonial design, Deluxe Breakfast, clean comfortable rooms, fitness center & sparkling pool. Close to area attrac More Check Rates

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